Systems-level computational modeling demonstrates fuel selection switching in high capacity running and low capacity running rats
Fig 7
Simulation families of HCR and LCR data.
HCR (blue circles) and LCR (red circles) rat exercise data [30] are as described in Fig 4. Several independent attempts were made to simulate the HCR and LCR data by independently adjusting the enzyme activities yielding 10 families of fits. All simulations are depicted by lines of the corresponding color (HCR (blue) and LCR (red)). Error bars represent standard error of the mean, while error bars in panel D were calculated from the propagation of error formula using errors in JCO2 and JO2 fluxes shown in panel A and B, respectively. LCR simulations (red lines) are truncated at 18 minutes in panels E-J for clarity. (A) HCR and LCR rat carbon dioxide flux (JCO2). (B) HCR and LCR rat molecular oxygen flux (JO2). (C) Plasma lactate from HCR and LCR. (D) Respiratory quotient (JCO2/JO2) for HCR and LCR. (E) Total C16-carnitine muscle concentration for HCR and LCR rats. (F) Total C14-carnitine muscle concentration for HCR and LCR rats. (G) Total C8-carnitine muscle concentration for HCR and LCR rats. (H) Total C4-carnitine muscle concentration for HCR and LCR rats. (I) Total acetyl-carnitine muscle concentration for HCR and LCR rats. (J) Total carnitine muscle concentration for HCR and LCR rats.