Differential tissue growth and cell adhesion alone drive early tooth morphogenesis: An ex vivo and in silico study
Fig 6
Parameter screening of differential adhesion parameters.
A, Tooth germ morphologies are shown with different combinations of mesenchymal homotypic adhesion and suprabasal homotypic adhesion values, while the other parameters are set to 1.0. High values of mesenchymal homotypic adhesion result in low growth angles whereas high values of suprabasal homotypic adhesion results in high growth angles. B, Morphologies are shown with different combinations of mesenchymal homotypic adhesion and epithelial-mesenchymal adhesion values (other adhesion parameters set to 1.0). High values of epithelial-mesenchymal adhesion result in low growth angles. Frontal sections shown. Colours as in Fig 3. All the simulations in this screening used the following growth parameters: sepi = 0.063, ssup = 0.021, smes = 0.182.