Differential tissue growth and cell adhesion alone drive early tooth morphogenesis: An ex vivo and in silico study
Fig 5
Comparison of cell movements with experimental data.
A, Experimental cell trajectories as shown in (6) (with permission). B, C, in silico trajectories (black lines) of suprabasal cells for hypothesis II and III respectively (same simulations as in Fig 4). D, empirical cell trajectories from Morita et al., highlighting a group of epithelial cells at the tip of each cervical loop. E, F, in silico trajectories of epithelial cells only for the morphologies shown in B and C respectively. Epithelial cells are shown before (green cylinders) and after (blue cylinder) the tracking interval and cell trajectories are shown as black lines. In hypothesis II (E), cells that were previously at the tip of the cervical loops move away from it and are replaced by cells coming from the centre by the end of the tracking period. In contrast, in hypothesis III (F) epithelial cells that start at the tip of the loops stay there after the tracking period, which is more consistent with the experimental data (D).