Differential tissue growth and cell adhesion alone drive early tooth morphogenesis: An ex vivo and in silico study
Fig 3
Parameter screening of the tissue specific proliferation rates (sepi, ssup and smes).
Variation in tooth germ morphology with different combinations of either sepi, ssup or smes, keeping the other two constant, under the different hypotheses (frontal sections depicted). A, B, E, variation in sepi for hypothesis I, II and III respectively (initial conditions depicted on the left). A, ssup = 0.022, smes = 0.10. B, ssup = 0.041, smes = 0.20, E, ssup = 0.029, smes = 0.20. In all cases, cervical loops form when sepi is relatively high and ssup is relatively low, but only in hypotheses II and III these are oriented downwards as in tooth development. C, F, Variation in ssup for hypotheses II and III respectively. C, sepi = 0.36, smes = 0.20. F, sepi = 0.045, smes = 0.20. Increasing values of ssup prevent the formation of cervical loops. D, G, Variation in tooth morphology for different values of smes under hypotheses II and III respectively. D, sepi = 0.50, ssup = 0.041. G, sepi = 0.082, ssup = 0.029. A relatively high mesenchymal proliferation is necessary for the proper formation of the cervical loops. Colours as in Fig 2. sepi, ssup and smes values are expressed in h-1.