Simulation enabled search for explanatory mechanisms of the fracture healing process
Fig 3
Discretized, images that map to sagittal sections through mouse tibia calluses.
(A) Discretized, colorized counterpart to day-7 tissue section in Fig 2A. The yellow-box area corresponds to the one in Fig 2A. The white box is the Target Region initial state. (B) Discretized, colorized counterpart of the day-10i tissue section. The white box is the Target Region final state. (C & D) Focus is drawn to the right sides. Arrows indicate directions of apparent local tissue changes. Some of that directional change that was ongoing in day-7 (C) continued into day-10 (D). Change in the other areas, particularly around the top edge of the Target Region, would have started after day-7. These apparent directional changes were taken into consideration for Mechanisms 2–4.