Simulation enabled search for explanatory mechanisms of the fracture healing process
Fig 1
This workflow sketch identifies key features and stages of our approach.
We have two concurrent long-term goals. 1) Build the case for plausible similarities—analogies—between Callus Subregion Analog final states (green boxes) and stained tissue sections in Fig 2 obtained from mouse 2 after 10 days of healing (shaded gray boxes). 2) Also build the case that strong analogies can exist between Analog Mechanisms and Processes occurring during execution and corresponding mouse callus healing mechanisms and processes at comparable granularities. An objective of this work is stage 6: demonstrate quantitative similarities between simulated final states and the day-10i Target Region.