In silico study of multicellular automaticity of heterogeneous cardiac cell monolayers: Effects of automaticity strength and structural linear anisotropy
Fig 3
Stochastic algorithm governing density and spatial distribution of pacemaker cells: An illustration.
(a) Blank geometry where all cells are quiescent. (b) Random attribution of the 1st pacemaker cell. (c) Determination of M1 available sites for aggregation and M2 available sites for nucleation in red and blue respectively. (d) Random nucleation of the 2nd pacemaker cell in M2 eventually because p ≤ pthr. (e) Determination of M1 and M2. (f) Random aggregation of the 3rd pacemaker cell in M1 eventually because p > pthr.