The exclusive effects of chaperonin on the behavior of proteins with 52 knot
Fig 4
Misfolded structures obtained in UCH-L1 folding.
Left: Changing the crossings in 52 knot results either in 31 or 01 knot (the crossings changed are marked with a circle). Middle: Comparison of the native structure of UCH-L1 (rainbow) with its misfolded structure (sandy)—upper panel—31, bottom—01 knot. Encircled is the crucial change in topology. Right: Enlargement of the topology-changing fragment. Note the different arrangement of sandy part of the chain.