The exclusive effects of chaperonin on the behavior of proteins with 52 knot
Fig 2
Schematic representation of possible folding pathways of UCHs.
The folding starts with a collapse, next, depending on which terminus becomes structured first, two topologically distinct pathways are possible. Lower arrows: the pathway where N-terminus is structured after C-terminus (FN), protein self-ties in one step (direct 01 → 52 transition). The upper arrows: pathway where C-terminus is structured last (FC)—the protein follows 01 → 31 → 52 pathway, where in the 31 knotted intermediate the N-terminus is in its native position, while C-terminus is not. Different background denotes different topology.