Optimizing homeostatic cell renewal in hierarchical tissues
Fig 7
Distribution of the generation times to second mutation, obtained from stochastic simulations, in the case where v depends on the compartment sizes.
We perform 5000 stochastic simulations and compare two arrangements of the compartment sizes: (a) constant compartment size (red bars) and increasing (blue bars); (b) decreasing (red bars) and increasing (blue bars). Compartment sizes are as in Fig 6. The self-renewal probabilities are v1 = 1, v3 = 0, , i = 1, 2. We assume n = 3 and u = 0.001. In part (a), the mean time to a two-hit mutant for constant and increasing architecture is 3.65 and 3.59 respectively; the p value obtained by a two-tailed t-test is p ≪ 0.001, the effect size is 0.12. In part (b), the mean time to a two-hit mutant for decreasing architecture is 3.73; p ≪ 0.001; the effect size is 0.30.