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Spike and burst coding in thalamocortical relay cells

Fig 12

Effects of reducing the h-type current.

The maximum conductance of the h-type current and the mean of the input current (-700 pA) were reduced with the same factor f in the bursting regime. This resulted in a reduction of both the burst rate and the number of spikes per burst, as can be seen from the example traces in A and the event frequencies in B. Reducing the h-type current and mean input current resulted in a reduction of the width of the membrane potential distribution, while keeping the mean membrane potential at the same level (D). A stronger deviation from the mean input current was needed to trigger a burst (C). The burst-triggered potassium (E), sodium (G) and T-type (I) currents and gating (F, H and J respectively) show that this reduction in the width of the membrane potential distribution affects all three currents.

doi: https://doi.org/10.1371/journal.pcbi.1005960.g012