Life cycle synchronization is a viral drug resistance mechanism
Fig 5
Stochastic competition between viral strains with different life cycle times.
Viral dynamics were simulated under periodic antiviral therapy given by the simple on-off model with a period (T) of 2 days and varying drug efficacy (f). The fixation probability (heat map color) is measured as the fraction of simulations in which a strain was the last surviving in the population and continued on to reach a steady state. (A) Results with n = 10 maturation steps. (B) Results with fixed maturation time τ = 1/m. The white dotted lines show where the average maturation time is equal to an integer multiple of the drug period. For all shown simulations, we assume the death rate of immature cells to be zero (dw = 0). 500 simulations were run for each drug efficacy level. Data shown for 21 different drug efficacies between f = 0.8 and f = 1.0, for competitions between 126 strains with average maturation times between 1 and 6 days. A version of the results for all drug efficacies is in S4 Fig, and a version with dw > 0 is in S5 Fig.