Identifying human diamine sensors for death related putrescine and cadaverine molecules
Fig 2
The orthosteric ligand-binding pocket of human TAAR6 and TAAR8.
Surface representation of the molecular models of hTAAR6 (A and C) and hTAAR8 (B and D) in the active- (top panels) and inactive-like (bottom panels) conformations. Extracellular view of the identified ligand binding cavities with molecular surfaces colored by the electrostatic potential calculated using the program APBS with nonlinear Poisson-Boltzmann equation and contoured at ±10 kT/e (negatively and positively charged surface areas in red and blue, respectively). Residues contributing to the electronegative potential of the binding pocket are represented in sticks and numbered according to the receptor type (Ballesteros-Weinstein scheme in parenthesis). Calculated distances between carboxyl moieties of Asp3.32 and Asp5.43 are shown for each molecular structure (yellow dashed lines). Protein backbones are shown in cylinders except ECL2 conformations (here omitted for clarity).