Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface
Fig 3
Enzymatic inhibition assay in the presence of RR compounds using the purified recombinant enzyme.
Red bars indicate the most active RR compounds promoting an enzyme inhibition as efficiently as APCP (5 μM) used as a positive control (green bar). Values of inhibitions are means from three independent experiments ± SD and negative values reflect enzyme activation.