Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission
Fig 7
Relatedness of polygenomic infections after multiple transmission events.
Line plots of the average relatedness of polygenomic infections (A,C) and proportion of simulations that have converged to the transmission of a single strain after multiple transmission events across 500 simulations (B,D). Only results from simulations where gametocyte-sampling probabilities are equal (A,B) and where gametocyte sampling probabilities are skewed by a 10:1 ratio between the most frequent and least frequent strain (C,D) are shown. Blue = No superinfection. Green = Superinfection where the resident strain is the same as one of the parental strains in the initial infection. Red = Superinfection where the resident strain is unrelated to the parental strains in the initial infection. Purple = Superinfection where the resident strain is unrelated and different in each transmission event. Solid dark lines indicate results where the initial polygenomic infection had a COI = 2 and light dotted lines indicate results where the initial polygenomic infection had a COI = 5.