A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment
Fig 13
Impact of the amplification factor, Ain and the differentiated cell death rate, δD on tumor growth.
Model predictions of the tumor volume vs. time for the control cases as well as for treatment with 1 or 5 mg/kg TCZ when A: the amplification factor, Ain, is slightly increased from its baseline value and when C: the differentiated cell death rate, δD is slightly decreased from baseline. Model predictions of the CSC percentage vs time for the control cases as well as for treatment with 1 or 5 mg/kg TCZ when B: the amplification factor, Ain, is slightly increased and when D: the differentiated cell death rate, δD is slightly decreased (D).