A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment
Fig 12
TCZ impact on CSC death, self-renewal, and percentage.
Model predictions of the temporal impact of administering 1mg/kg or 5mg/kg of TCZ on the A: death rate of CSCs, B: probability of CSC self-renewal and C: percentage of CSCs within the tumor. As mentioned in the Section 2.2, these predictions are based on training the model with data from [8] were primary tumor cells were transplanted into IL6 +/+ mice without the addition of human endothelial cells.