A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment
Fig 5
Numerical simulations of pre-treatment tumor growth, CSC percentage, and IL-6R fractional occupancy.
A: Best fit of the mathematical model prediction of tumor volume over time to the IL-6+/+ data for primary tumors implanted without human endothelial cells in [8]. The green curve in (A) shows the special case in which the tumor cells are not producing IL-6, ρ = 0. B: Comparison of the experimentally measured percentage of CSCs in primary tumors (brown), the experimentally measured percentage of CSCs on day 121 for tumors grown in IL-6 +/+ mice (blue), and the mathematical model prediction percentage of CSCs on day 121 (red). C: Model prediction of the temporal changes in the fractional occupancy of IL-6 receptors on CSCs, ϕS. D: Model prediction of the stem cell percentage over time.