Functional interrogation of Plasmodium genus metabolism identifies species- and stage-specific differences in nutrient essentiality and drug targeting
Fig 5
Stage-specific essentiality predictions of experimentally validated druggable targets and single-gene deletion experiments.
Comprehensive map of experimentally tested treatment targets for P. falciparum with stage-specific model predictions projected (in color) projected on top of the map. Colored reaction pathways correspond to drug inhibition studies (Table C in S1 Tables) and colored reaction names in rectangles correspond to single gene deletion experiments (Table B in S1 Tables). The color legend inset corresponds to iAM-Pf480 predictions. Validated drug targets that are also predictive to reduce growth in proliferative as well as late gametocyte stages are of particular interest. This comprehensive assessment of the model and experimental results enables stratification of existing drugs, new drugs to target, as well as new areas of metabolism warranting further investigation. See S2 Fig for the high resolution version of the figure.