Functional interrogation of Plasmodium genus metabolism identifies species- and stage-specific differences in nutrient essentiality and drug targeting
Fig 3
Life cycle stage specific models of P. falciparum predict gene targets that are essential for asexual, sexual and mosquito stages.
(a) The core and pan metabolic content of the genome-scale life cycle stage specific models of P. falciparum are 720 and 1002 reactions, respectively. (b-c) Parameters and AUC plots for performance evaluation of stage-specific pairwise differential gene expression comparisons following a similar approach to Nam, et al.[52] (S2 Fig). AUROC: area under the receiver operator curve (ROC), DEG: differential expression analysis, T: trophozoite, GII: early gametocyte stage, GV: late gametocyte stage, Ook: ookinete.