A systematic atlas of chaperome deregulation topologies across the human cancer landscape
Fig 7
Interactome-guided topographic maps of cancer chaperome shifts.
A. Cancer-specific chaperome meta-interactome networks, collapsing network nodes and edges onto meta-nodes and meta-edges, highlight cancer-specific gene expression changes of chaperome functional families in context of connectivity within the high-confidence physical interactome network (ME-CHAP) at reduced complexity. Node size and edge thickness correspond to the number of functional family member nodes and the sum of inter-family edges, respectively. Node colour indicates combined cancer gene expression changes based on Meta-PCA derived M-scores. LUAD = lung adenocarcinoma. B. Projecting differential changes between cancer and normal counterpart biopsy gene expression based on Meta-PCA derived M-scores (z dimension) onto the ME-CHAP interactome derived meta-network (see A) serving as base-grid layout (x-y dimensions), we derive cancer-specific interactome-guided 3D topographic maps. LUAD = lung adenocarcinoma. Both visualisations, meta-networks (A) and 3D-topographic maps (B) are accessible through the Proteostasis Profiler (Pro2).