A systematic atlas of chaperome deregulation topologies across the human cancer landscape
Fig 4
Proteasome and TRiC/CCT increase in human cancers reminisces stem cell proteostasis.
A. Heatmap indicates overall gene expression changes (∆GSA) of the human proteasome (43 genes, HGNC Family ID 690) throughout 22 TCGA solid cancers. Heatmap ∆GSA values are in the interval [-1, +1], where ‘+1’ indicates significant upregulation (p value = 0), while ‘-1’ indicates significant downregulation (p value = 0) as in Fig 2. B. Heatmap highlights HSP60 gene level differential expression of TRiC/CCT complex subunits throughout 22 TCGA solid cancers. Heatmap indicates significance of up- or downregulation of gene expression (t test) in cancer compared to matching healthy tissue (1—signed p value) in the interval [-1, +1], where ‘+1’ indicates significant upregulation (p value = 0), while ‘-1’ indicates significant downregulation (p value = 0). Blue highlights indicate Group 2 cancers (KICH, KIRC, KIRP, PCPG, and THCA).