A systematic atlas of chaperome deregulation topologies across the human cancer landscape
Fig 2
Chaperome gene expression alterations in human cancers.
Chaperome as compared to permutations of non-chaperome genes (A) and chaperome functional family (Level 2) (B) gene expression states in human cancer RNA-seq datasets from The Cancer Genome Atlas (TCGA) explored by Gene Set Analysis (GSA). Heatmaps indicate significance of up or down-regulation of cancer versus healthy gene expression as ∆GSA values in the interval [-1, +1], where ‘+1’ indicates significant upregulation (p value = 0), while ‘-1’ indicates significant downregulation (p value = 0). Chaperome functional families (B) are clustered by Euclidean distance (dendrograms). Bar graphs in A and B indicate functional family GSA group mean changes. Order of TCGA cancer groups (rows) in A is according to Euclidian distance of chaperome differential expression clustering (dendrogram) in B. Turquoise box highlights the human chaperome broken down into functional families in B. Yellow borders indicate marked clusters of chaperome functional family expression and separation of clusters I and II as separated by Euclidean distance clustering of TCGA cancer groups. TCGA cancer group acronyms: THYM (thymoma), ESCA (esophageal carcinoma), BRCA (breast invasive carcinoma), LUAD (lung adenocarcinoma), LUSC (lung squamous cell carcinoma), KICH (kidney chromophobe), STAD (stomach adenocarcinoma), CHOL (cholangiocarcinoma), LIHC (liver hepatocellular carcinoma), PRAD (prostate adenocarcinoma), HNSC (head and neck squamous cell carcinoma), KIRP (kidney renal papillary cell carcinoma), SARC (sarcoma), UCEC (uterine corpus endometrial carcinoma), BLCA (bladder urothelial carcinoma), PAAD (pancreatic adenocarcinoma), CESC (cervical squamous cell carcinoma and endocervical adenocarcinoma), GBM (glioblastoma multiforme), KIRC (kidney renal clear cell carcinoma), SKCM (skin cutaneous melanoma), PCPG (pheochromocytoma and paraganglioma), THCA (thyroid carcinoma).