Thalamocortical control of propofol phase-amplitude coupling
Fig 7
Propofol PAC regimes can be modeled as SWO connections between different gH-background excitation planes.
(A) Behavioral regimes of simulations across the gH-background excitation plane under low-dose propofol with no cortical firing (NCF). See Fig 3 for behavior regime legend. (B) Illustration of where each CF and NCF state lies on the SWO for trough-max: the blue, silent, depolarized CF state occurs during the corticothalamic SWO UP state, while the red, sustained alpha NCF state occurs during the corticothalamic SWO DOWN state. (C) Behavioral regimes simulations across the gH-background excitation plane under low-dose propofol with cortical firing (CF). (D) Representative TC cell voltage during SWO oscillation between the two states indicated in (A) and (C), illustrating trough-max. (E) Behavioral regimes of simulations across the gH-background excitation plane under high-dose propofol with NCF. (F) Illustration of where each CF and NCF state lies on the SWO for peak-max. (G) Behavioral regimes simulations across the gH-background excitation plane under high-dose propofol with CF. (H) Representative TC cell voltage during SWO oscillation between the two states indicated in (E) and (G), illustrating peak-max.