Thalamocortical control of propofol phase-amplitude coupling
Fig 3
Many thalamic oscillations, but not sustained alpha, occur across the baseline gH-background excitation plane.
(A) Behavioral regimes of baseline thalamic simulations across all physiological values of the gH-background excitation plane. Each simulation is represented by a pixel, colored according to its manually classified behavioral regime. Note the lack of sustained alpha (red) firing. (B) TC cell T-current de-inactivation "window" illustrated by the sum of steady-state activation (mT, blue) and de-inactivation (hT, red) curves. In our model, activation mT is always at steady-state, while the de-inactivation hT state variable must remain high enough for long enough to enable a spiking T-current burst. (C) Representative TC cell voltage trace during a silent, hyperpolarized stimulation and its zoom near the T-current de-inactivation window. (D) Representative TC cell voltage trace during a spindling simulation and its zoom. (E) Representative TC cell voltage trace during a sub-alpha simulation and its zoom. (F) Representative TC cell voltage trace during a silent, depolarized simulation and its zoom.