Thalamocortical control of propofol phase-amplitude coupling
Fig 1
Propofol PAC in EEG profile of stepwise-increasing propofol dose in human volunteers and accompanying illustrations.
(A) Illustration of theoretical propofol dose. (B) Illustration of theoretical response profile to auditory cues. (C) Spectrogram of frontal EEG during patient propofol administration. Note the alpha and SWO power between LOC and ROC. (D) PAC modulation of alpha amplitude to SWO phase for same patient. Note the strong, stereotyped trough-max PAC when LOC occurs, and the subsequent 180 degree shift in PAC to peak-max upon deeper propofol administration. (E) Illustration of theoretical EEG traces from representative signals of either PAC regime. Based on Figure 1 of [12].