Astrocytic Kir4.1 channels and gap junctions account for spontaneous epileptic seizure
Fig 4
(a) The decay factor t1/e is proposed here. (b) A schematic diagram of extracellular K+ concentration ([K+]o) and the decay factors t1/e as published in experimental results (see Fig. 5B from [17]). Black spots and gray spots are experimental data obtained from connexin30-/- rats and control gap junction rats, respectively. (c) The relationship between extracellular K+ concentration and decay factor t1/e in control conditions or the gap junction-deficient state. The dashed lines and solid lines denote experimental fitted curves (see Fig. 5B from [17]) and fitted curves from numerical simulation data, respectively. (d) Statistical error for experimental and numerical fitted curves for different strengths of gap junctions. (e) K+ undershoot in the extracellular space with different gap junction strengths after the same external stimuli sequence. Other parameters used are the same as in Fig 1.