Astrocytic Kir4.1 channels and gap junctions account for spontaneous epileptic seizure
Fig 1
(a) A schematic of the single neuronal model dynamics. (b) The concept of undershoot is proposed here, with the total surface area of the undershoot estimated (gray area). The duration of the undershoot (“time of return”) corresponds to the time needed for [K+]o to recover to the basal level after the end of the stimulation. (c) The time series of extracellular K+ concentration after different sine stimulation periods when Kir4.1 channels are in controlled states, such as 30 s, 10 s, 100 ms, from simulation results (left) and experiments interpolated for comparison (right) from Fig 3 in Chever O et al [35]. (d) K+ concentration in the extracellular space ([K+]o) and astrocyte ([K+]A) response to Kir4.1 channel in controlled and blocked states during and after 10 s sine stimulus spike. Simulation results (1); experiments correspond to results interpolated from Fig 7 in Ballanyi K et al [36]. For other parameter values, see Table 1. In addition, ɛ = 1.2/s-1 and Kbath = 4 mM.