Electrical stimulus artifact cancellation and neural spike detection on large multi-electrode arrays
Fig 9
Analysis of responses of neurons in a neighborhood of the stimulating electrode.
A Spatial configuration: stimulating electrode (blue/yellow annulus) and four neurons on its vicinity. Soma of green neuron and axon of pink neuron overlap with stimulating electrode. B Activation curves (solid lines) along with human-curated and algorithm inferred spike probabilities (gray and colored circles, respectively) of all the four cells. Stimulation elicited activation of green and pink neurons; however, the two other neurons remained inactive. C Raster plots for the activated cells, with responses sorted by stimulation strength in the y axis. Human and algorithm inferred latencies are in good agreement (gray and colored circles, respectively). Here, direct somatic activation of the green neuron leads to lower-latency and lower-threshold activation than of the pink neuron, which is activated through its axon.