Electrical stimulus artifact cancellation and neural spike detection on large multi-electrode arrays
Fig 5
Example of neural activity and artifact inference in a neighborhood of the stimulating electrode.
Left: Two recordings in response to a 2.01 μA stimulus. Center: estimated artifact (as the stimulus doesn’t change, it is the same for both trials). Right: Difference between raw traces and estimated artifact, with inferred spikes in color. In the first trial (above) one spiking neuron was detected, while in trial 2 (below) three spiking neurons were detected. The algorithm separates the artifact A and spiking activity s effectively here.