Concerted regulation of npc2 binding to endosomal/lysosomal membranes by bis(monoacylglycero)phosphate and sphingomyelin
Fig 4
Normalized contact frequency analysis (ncf).
A) The black rectangles show the ncf averaged over all bmp mixtures (bmp:chol:sm:dopg:popc = 20:10:0:0:70 (System 5), 20:35:0:0:45 (System 6) and 20:10:20:0:50 (System 7)), and the gray bars show the standard deviation. B) Representative snapshots showing npc2 interacting with bmp in Prone mode (left) and Supine mode (right). The protein is colored based on the ncf and the residues with ncf > 0.4 are shown in licorice and labeled.