Base pair probability estimates improve the prediction accuracy of RNA non-canonical base pairs
Fig 5
Prediction of non-canonical base pairs by predicting the conserved structure with multiple homologous sequences for (A) an MVE virus nuclease resistant RNA, (B) a D. radiodurans SRP hairpin domain, and (C) a O. sativa Twister ribozyme. Prediction accuracy is shown for structures composed of highly probable pairs using information from a single sequence (blue) or a TurboFold calculation on 10 sequences (red). In panels A and B, no blue line is present because the single sequence prediction did not correctly predict any pairs. Also shown is prediction using evolutionary couplings from the plmc program [16] (green).