Competitive tuning: Competition's role in setting the frequency-dependence of Ca2+-dependent proteins
Fig 4
Competition tunes activation frequencies.
(A) and (B) show normalized activation of CaM as a function of frequency for the isolated and competitive models, respectively. Red denotes peak activation; blue denotes minimal activation. Frequency windows of peak activation tend to narrow and shift for many of the binding partners in the competitive case. Indeed, (C) indicates a sharpening of activation frequency windows as an increase in specificity in the competitive model, at least for most proteins. Specificity is Sb multiplied by 100 percent.