General principles of binding between cell surface receptors and multi-specific ligands: A computational study
Fig 3
We systematically changed both AB binding affinity and CD binding affinity simultaneously.
The overall testing results are plotted as two-dimensional contour profiles. The AB binding affinity is indexed along x axis, while the CD binding affinity is indexed along y axis. The color index of the contours indicates the number of interactions, as shown on the right side of the figure. The numbers of AB interactions formed in the first scenario are illustrated in (a) under all combinations of AB and CD affinities, while the numbers of CD interactions are given in (b). For the second scenario, the numbers of AB and CD interactions are recorded in (c) and (d), respectively. Finally, the numbers of AB interactions formed in the third scenario are plotted in (e) and the numbers of CD interactions are plotted in (f).