Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments
Fig 5
Probability of reconstitution from a single donor HSC which is injected into a preconditioned host.
Symbols are results from 105 simulations of the stochastic model. For efficiency we ran the simulations until the population reached either 0 (extinction) or 100 (reconstitution), and we assume no further extinction events occur once this upper limit has been reached. Dotted lines are the ‘first-order’ prediction of Eq (10). Solid lines are the predictions of Eq (11) which account for detachments, reattachments, and reproduction events. Remaining parameters are as in Table 1.