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Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments

Fig 3

Initial chimerism of neutral donor cells in a healthy, non-preconditioned host.

Upper panels depict the level of donor chimerism shortly after a dose of neutral donor cells, , is injected into the host. Symbols are from numerical integration of Eq (2). The small-dose regime is described by Eq (3) (solid lines for ), and the large-dose regime is described by Eq (9) (solid lines for ). Lower panels show the accuracy of these approximations when compared to the numerical integration of Eq (2). This error takes the form (approx. − exact)/exact. (a) s* = 10, and (b) s* = 100. The lifetime in the PB, ℓ, is measured in minutes. Remaining parameters are as in Table 1.

doi: https://doi.org/10.1371/journal.pcbi.1005803.g003