Image-based model of the spectrin cytoskeleton for red blood cell simulation
Fig 9
Comparison of static and dynamic spectrin networks under deformation typical of an optical tweezer experiment.
(a) Heat map on the cell surface representing the number of irreversibly broken edges on the static (blue) and dynamic with koff = 10s−1 (red) networks at several instants in time. The static network has an excess of irreversibly broken edges at the cell ends, as illustrated by the deep blue color, (b) Dynamic networks (koff = 10s−1, red symbols and koff = 100s−1, black symbols) accumulate fewer irreversibly broken edges under a prescribed strain than the static network (koff = 0s−1, blue symbols). Error bars were computed by performing each simulation at 64 × 64 × 128 and 128 × 128 × 256 grid resolutions, (c) Final state of stretched membrane with irreversibly broken edges overlaid from dynamic network (red edges) and static network (blue edges) simulations.