Image-based model of the spectrin cytoskeleton for red blood cell simulation
Fig 7
Behavior of a dynamic cytoskeleton under shear flow.
(a) I2/I1 over time for koff = 0, 10, and 100 s−1, (b) The lower effective shear modulus for a dynamic network leads to a higher dimensionless capillary number and greater deformations, as evidenced by the greater maximum value of I1 for the network with the fastest rate of remodeling, (c) The total number of irreversibly broken edges is plotted versus time. The network with the fastest dynamics, i.e. koff = 100s−1, accumulates the most irreversibly broken edges in shear flow. The benefit of having more edges that spontaneously disconnect before breaking is outweighed by the cost of decreased shear resistance and greater extension.