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The ins and outs of vanillyl alcohol oxidase: Identification of ligand migration paths

Fig 8

Structure-based sequence alignment of VAO, EUGO and PCMH.

Numbering of residues at the beginning and end of each line correspond to the numbering used in the crystal structures. Numbers on top of the alignment correspond to the numbering of VAO sequence P56216.1 and is the same as used throughout this study. Coloured symbols indicate the path the residue underneath it is involved in. Orange, blue, magenta and cyan was used for the cap, the FAD, the subunit interface and the re path respectively. Red indicates functionally important residues. Bi-coloured symbols indicate the residue is involved in two paths. The shape of the symbol indicates preservation of the residue, stars (present in all three structures), circles (present in two of the three structures) and squares (present in only one of the three structures).

Fig 8

doi: https://doi.org/10.1371/journal.pcbi.1005787.g008