Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics
Fig 6
Structural rearrangement at the EC/TM domains interface during ion-channel deactivation.
On top, the location of the strictly conserved proline (P268) at the EC/TM interface is shown. The four transmembrane helices and the position of P268 in the active (red) and resting (green) states are indicated. On bottom, the spatial distribution of the center of mass of the five P268 on the plane parallel to the membrane is shown for GluCl active with (red) and without IVM (blue), and GluCl resting (green). The center of the pore is represented by a large black dot.