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A continuum-mechanical skeletal muscle model including actin-titin interaction predicts stable contractions on the descending limb of the force-length relation

Fig 8

Top: Total, active, and passive force—length relations. Superimposed on the total stress curve are, for a muscle length of L/L₀ = 1.5, the half-sarcomere lengths predicted by models and M^Fv (red crosses), and models M_ATI and (blue dot). The value predicted by models M_ATI and coincides with the theoretically predicted stress—stretch value. Bottom: Histogram of half-sarcomere lengths in models and M^Fv (red), and models M_ATI and (blue, scaled for readability). Under conditions of steady state (after 2.5 s), the results of models and M^Fv, as well as those of models M_ATI and , coincide.

doi: https://doi.org/10.1371/journal.pcbi.1005773.g008