Dynamics and heterogeneity of brain damage in multiple sclerosis
Fig 4
Sensitivity analysis of the model’s parameters.
A) A sensitivity analysis showing the effects of the uncertainties in parameters on the model’s behavior (output variables: EDSS and brain volume—BV). The extended version of a Fourier amplitude sensitivity test (eFAST) was used to quantify the relative importance of the input factors. Pink line indicates the sensitivity level of a dummy parameter that does not occur in any of the equations. Sensitivities below this line should not be considered significantly different from zero. B) Simulations of brain volume in MS. Median occurrence and interquartile range (IQR) for the correlation coefficients between the experimental and simulated BVs in the validation cohort. Pearson correlation coefficients: cluster 1, 0.93; cluster 2, 0.94; cluster 3, 0.86; and cluster 4, 0.87.