Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer
Fig 3
Oscillation frequency and firing rates for patch activation with different input firing frequencies.
A: network mean oscillation frequency versus average mossy fiber firing rate versus for 100 and 200 μm ON patch radius, with and without gap junctions. B, C, D: Same as A for mean GoC firing rate, mean GrC firing rate, network synchronization index, respectively. Membrane potentials of example neurons are shown in S1A–S1D Fig. With the 200 μm patch radius, mossy fiber firing rates above 50 Hz caused depolarization block of GoCs and this data was discarded. E: Volumetric maps representing network activity at different times during a 60Hz patch stimulus. Full sequence is available in S1 Movie. The blue and green dots represent mossy fiber and GoC activity respectively, while gray dots represent non-spiking neurons. The small red points are active GrCs. Notice, from left to right, the activations of mossy fibers in the central patch, leading to increased GrC activity in the patch and followed by activation of a beam of GoCs. The inset in C represents the same configuration as the one in Fig 2. Data are mean±standard deviation.