Allosteric conformational change cascade in cytoplasmic dynein revealed by structure-based molecular simulations
Fig 6
Summary of the conformational change cascade in the power-stroke (left-half) and the recovery-stroke (right-half) processes.
The open and filled symbols represent the pre- and post-power-stroke states, respectively. Only for the MTBD, we used a three-state representation with the shaded circles being in a highly fluctuating state. The thickness of arrows indicates probabilities. The numbers associated with arrows represents the numbers of trajectories. Linker in purple, AAA1 in blue, AAA2 in cyan, AAA3 in green, AAA4 in yellow, stalk~MTBD in grey, AAA5 in orange, and AAA6~C-sequence in red.