Exploiting ecology in drug pulse sequences in favour of population reduction
Fig 4
a-c) For a sequence of three pulses, the global population minimum can occur during any of the pulses, depending on the pulse parameters (a: tr = 6, s = 0, b: tr = 30, s = 0, c: tr = 45, s = −0.2; τ = 60 for all). The local minimum (within one pulse) is marked with a light green dot, the global minimum is marked with a green cross. In a, the value of n at the minima (green dots) increases successively, such that global minimum occurs during the first pulse. This is because τ − tr is large. For b and c, τ − tr decreases, implying that the global minimum shifts into the second and third pulse, respectively. Panels d-e show that for s = −1, the minimum is attained in the second pulse (d), unless is so long that the population can regrow to
(e).