Modeling antibiotic treatment in hospitals: A systematic approach shows benefits of combination therapy over cycling, mixing, and mono-drug therapies
Fig 1
Schematic diagram of the dynamical model given by Eqs 1–5.
The variables X, S, R1, R2, and R3 represent uninfected patients, and patients infected with a sensitive strain, a strain resistant to drug 1, a strain resistant to drug 2, and a strain resistant to both drugs, respectively.