A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence
Fig 6
Knockouts that cause in-silico IL-6 and IL-8 inhibition for NEMO knockout.
NEMO is switched off (NEMO = 0) preventing NF-κB signaling from being activated. The outcome is similar to the two previously described simulations in Figs 4 and 5.