A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence
Fig 4
Knockouts that cause in-silico IL-6 and IL-8 inhibition for NFkB knockout.
Network states present the gene activity of all genes in the model. Green boxes indicate gene activation while red boxes show gene inactivation. A knock-down or overexpression is simulated by setting a gene to 0 or 1, respectively. This simulation shows the time course of expected states after DNA damage with NF-κB switched off (NFkB = 0) which leads to an inhibition of proinflammatory signaling.