Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activity
Fig 3
Overview of IRES global sequence features.
(A) Robust and predictive global k-mer count features that appear in at least two IRES sequence groups; features were divided into classes based on their nucleotide composition and interpretation (vertical bars). For each feature, its effect (feature importance taken with sign “+” if the feature was classified as positive, and with sign “−” otherwise) is shown, and non-robust features are marked with a cross. (B) Comparison of C-rich pyrimidine tract feature importances across three viral sequence groups; non-robust features are shown with hatched bars. (C) Sequence GC content distribution for the defined sequence groups.