Mathematical modeling and quantitative analysis of HIV-1 Gag trafficking and polymerization
Fig 1
Schematic representation of a model cell.
rN, rC are the nuclear and cellular radius, respectively. In the cytoplasm (rN < r < rC), Gag monomers can aggregate to dimers, but not higher-order polymers. Monomers and dimers are transported actively by molecular motors along microtubules and can diffuse along the direction of the concentration gradient. Underneath the plasma membrane (rC), monomers can be polymerized to hexamers.